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Lipid peroxidation mainly includes the reaction of ROS with lipid molecules in cell membranes, raising membrane fluidity and permeability, thereby having an impact on cell structure and function ( Moreover, DNA damage activates stress response mechanisms within cells, possibly causing apoptosis or mutation, further compromising the health of gingival tissues ( 2.3.3 Depletion of antioxidant systems During the prolonged progression of chronic periodontitis, oxidative stress persists, causing depletion and imbalance of antioxidant systems ( 3 Antioxidants and their roles 3.1 Types and functions of main antioxidants Antioxidants are compounds which is capable of neutralizing and clearing oxygen free radicals and other oxidants within cells, having a huge impact on the prevention and treatment of chronic inflammatory diseases

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These restrictions and warnings demonstrate the FDA’s stringent consideration of patient safety in the drug approval process